Adrian began to grow in 1891 when Postmaster W.R. Smith opened and operated a post office there. Immediately after the post office opened, Adrian became a railroad town and trading hub.
Somewhat strangely, Adrian lies between two counties, the consequence of a dispute between landowners Joe Hutcheson and Burrel Kea. Both Hutcheson and Kea wanted to build bridge over the Ohooppee River, and ultimately, Kea won the rights to do so. Angered by this, Hutcheson influenced the legislature to create a new county line for Johnson and Emanuel Counties; thereafter, none of Kea's land extended into Hutcheson's county.