Tennille has been a bustling community ever since the beginning of the 20th century. Its railroad incorporated in 1881, the Tennille Banking Company opened in 1900, and the city's public school system opened in 1901. On a busy business day the city's main square teamed with people.
Tennille served as home for ten years to the architect Charles E. Choate, who designed numerous buildings that are now in the National Register of Historic Places. His creations include Stilmore's First Methodist Episcopal Church, Sandersville's Holt Brothers Banking Company Building, Tennille's Thomas W. Smith House and Atlanta's Park Street Methodist Episcopal Church.